BackgroundThe diagnosis of AITL is challenging.It may be delayed or even missed due to critical clinical conditions and its histologic and immunophenotypic overlap with other neoplastic and reactive lymphoid proliferations.ObjectiveThe key objective is to obtain an efficient diagnosis, sensitive disease monitoring and treatment efficacy assessment
Abstract The critical function of dihydroorotate dehydrogenase (DHODH) in pyrimidine synthesis attracted a great interest throughout beyond decades.Inhibitors of human DHODH (hDHODH) have validated efficacy for remedy of many immunological diseases.Brequinar and leflunomide are examples of such compounds.However, most of such immunosuppressive medi
Abstract Pairing semiconductors with electrochemical processing offers an untapped opportunity to create novel nanostructures for practical devices.Here we report the results of one such pairing: the in-situ formation of highly-doped, interface-matched, sharp nanocrystalline homojunctions (NHJs) with single step electrodeposition of two copper-indi
Heat transfer analysis can be studied efficiently with the help of so-called modern dimensional analysis (MDA), which offers a uniform and easy approach, without requiring in-depth knowledge of the phenomenon by only taking into account variables that may have some influence.After a brief presentation of the advantages of this method (MDA), the aut
Summary: Health Technology Assessment (HTA) for reimbursement of all new cancer drugs in the European Union (EU) will be evaluated for all member states by a central European HTA starting Chest Freezer in 2025.EU HTA guidelines for applicants under these new regulations put the focus on meta-analysis of aggregated randomized trial data and are in c